ScholarWorks@숙명여자대학교

초록

Biological monitoring, analyses of internal dose for exposure to toxicants, has been thought as one of thebest approaches for risk assessment. As the amount detected in human samples is generally very low, typicallyin the parts-per-bilion (ppb) or parts-per-trillion (ppt) range, analytic technologies such as HPLC, GC/MS,LC/MS, and LC/MS/MS have been continuously developed. In addition, route specific and sensitive exposurebiomarkers have been developed for proper biological monitoring. PBPK modeling, particularly reverse dosimetry, has been emphasized as an useful method via interpretationof biological monitoring results for regulation of toxicants. Thus, this review is focused on the use of PBPKdosimetry models for toxicology research and risk assessment in Korea.

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