상세 보기
- Ahn, Jongmin;
- Pei, Yihua;
- Chae, Hee-Sung;
- Kim, Seong-Hwan;
- Kim, Young-Mi;
- ... Chang, Minsun;
- ... Song, Yun Seon;
- 외 8명
WEB OF SCIENCE
2SCOPUS
2초록
Bioactivity-guided fractionation for the stems of leaves of Larrea nitida Cav., using interleukin-6 (IL-6) inhibitory assay in human mast cells (HMC-1), led to the isolation of three new compounds with an unprecedented skeleton in nature (1-3) and three known compounds (4-6). Their structures were elucidated through extensive spectroscopic analysis. The three new compounds were elucidated as two new spiroketones, nitidaones A (1), and B (2) and one new biphenyl analog, nitidaol (3). The known compounds were identified as nordihydroguaiaretic acid (4), 7,3',4'-tri-O-methylquercetin (5) and ayanin (6). All the isolates were tested for their inhibitory activity against IL-6 production in HMC-1 cells. Of them, compounds 1, 3-6 showed potent anti-inflammatory activity, with IC50 values of 12.8, 17.5, 14.9, 22.9, and 17.8 mu M, respectively.
키워드
- 제목
- Spiroketones and a Biphenyl Analog from Stems and Leaves of Larrea nitida and Their Inhibitory Activity against IL-6 Production
- 저자
- Ahn, Jongmin; Pei, Yihua; Chae, Hee-Sung; Kim, Seong-Hwan; Kim, Young-Mi; Choi, Young Hee; Lee, Joongku; Chang, Minsun; Song, Yun Seon; Rodriguez, Roberto; Oh, Dong-Chan; Kim, Jinwoong; Choi, Sangho; Joo, Sang Hoon; Chin, Young-Won
- 발행일
- 2018-02
- 유형
- Article
- 저널명
- Molecules
- 권
- 23
- 호
- 2