ScholarWorks@숙명여자대학교

초록

Korean pears and Chlorella have shown potential in detoxifying various xenobiotics. Thus, we investigated their combined effects on the detoxification of endocrine-disrupting chemicals (EDCs), and EDC-related fat and muscle health using a non-inferiority clinical trial and in vivo and in vitro tests. The human doses of pear extracts, chlorella, and positive control (L-carnitine tartrate) were safe levels, based on previous clinical trials and the approvement by Korean government. The combination increased hand grip strength. Total cholesterol, lowdensity lipoprotein, apoA-I, and apoB levels were alleviated by the combination, which also modulated ACC, FASN, and HSL to affect fatty acid synthesis and lipidosis or R-oxidation in high-fat-diet- and bisphenol-A-treated mice and in 3 T3-L1 adipocytes. Consistently, in vitro experiments showed that the combination treatment suppressed adipocyte differentiation, downregulated PPAR gamma expression, promoted lipid breakdown, and enhanced myoblast differentiation. In conclusion, the combination can be useful to prevent from EDCs on fat and muscle health.

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