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Structural Diversification of Pyrazinone Metabolites via Spontaneous Oxa-Michael Addition in <i>Staphylococcus xylosus</i>
- Lee, Ju Ryeong;
- Hwang, Su Jung;
- Choi, Yukyung;
- Kim, Jonghwan;
- Lee, Gyu Sung;
- ... Kang, Kyo Bin;
- 외 4명
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1초록
A family of pyrazinone metabolites (1-11) were characterized from Staphylococcus xylosus ATCC 29971. Six of them were hydroxylated or methoxylated, which were proposed to be produced by the rare noncatalytic oxa-Michael addition reaction with a water or methanol molecule. It was confirmed that isopropyl alcohol can also be the Michael donor of the reaction. 1-7 and the synthetic precursor 2a showed significant inhibition of breast cancer cell migration.
- 제목
- Structural Diversification of Pyrazinone Metabolites via Spontaneous Oxa-Michael Addition in <i>Staphylococcus xylosus</i>
- 저자
- Lee, Ju Ryeong; Hwang, Su Jung; Choi, Yukyung; Kim, Jonghwan; Lee, Gyu Sung; Lee, Bum Soo; Kim, Ki Hyun; Kang, Kyo Bin; Lee, Hyo-Jong; Kim, Chung Sub
- 발행일
- 2024-07
- 유형
- Article; Early Access
- 권
- 87
- 호
- 7
- 페이지
- 1881 ~ 1887