마우스 악성흑색종세포에서 L-Arginine이 항산화작용과 멜라닌생성에 미치는 영향

초록

Pigmentation protects cells from harmful effects of sunlight or oxidative stress. It is due to the synthesis and dispersion of melanin. Our study has shown to melanogenesis effect of L-arginine on B16F10 cells, murine melanoma cells. L-arginine (0∼200 mM) exhibited effective cell growth inhibition dosedependently. L-arginine decrease level of ROS (reactive oxygen species). Further investigation revealed that L-arginine is a factor of melanogenesis. tyrosinase activity and Melanin contents increased dose dependent manner. Taken together, these findings suggest that L-arginine has to decrease the level of ROS, and increase tyrosinase activity and melanogenesis. (Cancer Prev Res 14, 242-247, 2009)

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