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초록
Pigmentation protects cells from harmful effects of sunlight or oxidative stress. It is due to the synthesis and dispersion of melanin. Our study has shown to melanogenesis effect of L-arginine on B16F10 cells, murine melanoma cells. L-arginine (0∼200 mM) exhibited effective cell growth inhibition dosedependently. L-arginine decrease level of ROS (reactive oxygen species). Further investigation revealed that L-arginine is a factor of melanogenesis. tyrosinase activity and Melanin contents increased dose dependent manner. Taken together, these findings suggest that L-arginine has to decrease the level of ROS, and increase tyrosinase activity and melanogenesis. (Cancer Prev Res 14, 242-247, 2009)
키워드
L-Arginine; Antioxidant activity; Melanogenesis; Murine melanoma cells; ROS
- 제목
- 마우스 악성흑색종세포에서 L-Arginine이 항산화작용과 멜라닌생성에 미치는 영향
- 제목 (타언어)
- The Effect of L-Arginine on Antioxidant Activity and Melanogenesis in Murine Melanoma Cells
- 저자
- 송경희; 유지선; 김안근; 김미지
- 발행일
- 2009-09
- 저널명
- 대한암예방학회지
- 권
- 14
- 호
- 3
- 페이지
- 242 ~ 247