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초록
hNQO1 is a promising target for cancer diagnosis and treatment. Here, we developed a coumarin-naphthalimide hybrid (1) as a dual emissive fluorescent probe that enhances the emission through hNQO1-mediated cleavage of its trimethyl lockquinone moiety. Probe 1 can be used for a real-time monitoring of hNQO1 activity in living cells. © 2019
키워드
Coumarin; Dual emission imaging; hNQO1 detection; Naphthalimide; Fluorescence; Cancer diagnosis; Coumarin; Dual emissions; Fluorescent probes; Living cell; Naphthalimide; Real time monitoring; Trimethyl; Probes; Cells; Diagnosis; Emission; Fluorescence; Measuring Instruments; Monitoring; Processing
- 제목
- A coumarin-naphthalimide hybrid as a dual emissive fluorescent probe for hNQO1
- 저자
- Park, Sun Young; Won, Miae; Kang, Chulhun; Kim, Jong Seung; Lee, Min Hee
- 발행일
- 2019-05
- 유형
- Article
- 권
- 164
- 페이지
- 341 ~ 345