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초록
Reactive oxygen species (ROS) are produced in the metabolic process of oxygen in cells. The superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in cells systemize the antioxidative enzymes to control the oxidative stress. Daidzein is one of the isoflavonoids, and its role in controlling cellular oxidative stress is presently the active issue at question. In this study, we analyzed daidzein-induced survival rates of the CHO-K1 cells, activities of antioxidative enzymes, ROS levels, and expression levels of antioxidative enzyme genes in order to investigate the effect of daidzein on cellular ROS production and antioxidative systems. As results, the survival rate of cells was decreased as the dose of daidzein increases (12.5～200μM). Daidzein increased cellular ROS levels in a dose-dependent manner, while it reduced total SOD activities and the expression of CuZnSOD. In conclusion, we suggest that daidzein induces oxidative stress via down relation of SOD-related mechanisms. (Cancer Prev Res 11, 321-328, 2006)
키워드
- 제목
- 햄스터 난소세포에서 Daidzein이 항산화효소활성과 발현에 미치는 영향
- 제목 (타언어)
- Effect of Daidzein on Activity and Expression of Antioxidant Enzyme in Hamster ovary cells
- 저자
- 김민혜; 김안근
- 발행일
- 2006-12
- 저널명
- 대한암예방학회지
- 권
- 11
- 호
- 4
- 페이지
- 321 ~ 328