Bromoacetophenone-based photonucleases: Photoinduced cleavage of DNA by 4 '-bromoacetophenone-pyrrolecarboxamide conjugates

초록

[GRAPHICS]4'-Bromoacetophenone derivatives which upon excitation can generate monophenyl radicals capable of hydrogen atom abstraction were investigated as photoinducible DNA cleaving agents. Pyrrolecarboxamide-conjugated 4'-bromoacetophenones were synthesized, and their DNA cleaving activities and sequence selectivities were determined.