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Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia
- Jin, Guo Hua;
- Ha, Sang Keun;
- Park, Hye Min;
- Kang, Bomi;
- Kim, Sun Yeou;
- ... Jeon, Raok;
- 외 2명
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27초록
A series of azaisoflavones were synthesized and their biological activities were evaluated for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in BV-2 microglia cell lines. Among these compounds, compound 8d was the most potent with IC(50) 7.83 mu M for inhibition of NO production. Also, compound 8d inhibited expression of iNOS in LPS-induced BV2 cells. This result suggests that compound 8d inhibited the production of NO by suppressing the expression of iNOS. (c) 2008 Elsevier Ltd. All rights reserved.
키워드
azaisoflavone; nitric oxide; iNOS; PROTECTS DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE; INFLAMMATION; MECHANISMS; GENISTEIN; CELLS; SYSTEMS; IMMUNE
- 제목
- Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia
- 저자
- Jin, Guo Hua; Ha, Sang Keun; Park, Hye Min; Kang, Bomi; Kim, Sun Yeou; Kim, Hee-Do; Ryu, Jae-Ha; Jeon, Raok
- 발행일
- 2008-07-15
- 유형
- Article
- 권
- 18
- 호
- 14
- 페이지
- 4092 ~ 4094