Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia

Jin, Guo Hua; Ha, Sang Keun; Park, Hye Min; Kang, Bomi; Kim, Sun Yeou; Kim, Hee-Do; Ryu, Jae-Ha; Jeon, Raok

doi:10.1016/j.bmcl.2008.05.106

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Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia

Jin, Guo Hua;
Ha, Sang Keun;
Park, Hye Min;
Kang, Bomi;
Kim, Sun Yeou;
... Jeon, Raok;
외 2명

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27

초록

A series of azaisoflavones were synthesized and their biological activities were evaluated for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in BV-2 microglia cell lines. Among these compounds, compound 8d was the most potent with IC(50) 7.83 mu M for inhibition of NO production. Also, compound 8d inhibited expression of iNOS in LPS-induced BV2 cells. This result suggests that compound 8d inhibited the production of NO by suppressing the expression of iNOS. (c) 2008 Elsevier Ltd. All rights reserved.

키워드

azaisoflavone; nitric oxide; iNOS; PROTECTS DOPAMINERGIC-NEURONS; PARKINSONS-DISEASE; INFLAMMATION; MECHANISMS; GENISTEIN; CELLS; SYSTEMS; IMMUNE

제목: Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia

저자: Jin, Guo Hua; Ha, Sang Keun; Park, Hye Min; Kang, Bomi; Kim, Sun Yeou; Kim, Hee-Do; Ryu, Jae-Ha; Jeon, Raok

DOI: 10.1016/j.bmcl.2008.05.106

발행일: 2008-07-15

유형: Article

저널명: Bioorganic & Medicinal Chemistry Letters

권: 18

호: 14

페이지: 4092 ~ 4094

언어: ENG

출판사: PERGAMON-ELSEVIER SCIENCE LTD

발행국가: 영국

분량: 3 페이지

ISSN: E 1464-3405
P 0960-894X