상세 보기
초록
Four flavones, 3,4'- O- dimethylquercetin (1), 3,7- O- dimethylquercetin (2), 3- O- methylquercetin (3) and 3,7,4'- O- trimethylquercetin (4) were isolated as the inhibitors of nitric oxide production in activated microglia (IC50 values: 11.1, 4.2, 3.8, and 25.1 mu M, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC50 values of 1.75 and 0.77 mu M, respectively. (C) 2007 Elsevier Ltd. All rights reserved.
키워드
Siegesbeckia glabrescens; nitric oxide synthase; peroxynitrite; NITRIC-OXIDE PRODUCTION; INFLAMMATORY RESPONSE; CELLS; LIPOPOLYSACCHARIDE; PEROXYNITRITE; APOPTOSIS; MICROGLIA; DISEASES; SYSTEM; NO
- 제목
- In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens
- 저자
- Kim, Jae Yeon; Lim, Hyo Jin; Ryu, Jae-Ha
- 발행일
- 2008-02-15
- 유형
- Article
- 권
- 18
- 호
- 4
- 페이지
- 1511 ~ 1514