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초록
Autophagy is a process for the degradation and recycling of intracellular components and dysfunctional organelles. We developed an indole-embedded fluorescent naphthalimide for the selective imaging of autophagosomes in live cells. It was shown as intense puncta in the fluorescence confocal images and co-localizes with an autophagosome marker, LC3-RFP. In addition, it was applied to cellular autophagic models based on ER stress and starvation to verify its capability.
키워드
MONITORING AUTOPHAGY; EXPRESSION; STRESS; PROBE
- 제목
- An indole-based fluorescent chemosensor targeting the autophagosome
- 저자
- Park, Sun Young; Kim, Kyutae; Cho, Dong-Hyung; Jo, Eun-Young; Kang, Chulhun; Lee, Min Hee
- 발행일
- 2022-02
- 유형
- Article
- 권
- 58
- 호
- 17
- 페이지
- 2886 ~ 2889