ScholarWorks@숙명여자대학교

초록

Superoxide dismutases (SODs) are essential antioxidantenzymesthat prevent massive superoxide radical production and thus protectcells from damage induced by free radicals. However, this concepthas rarely been applied to directly impede the function of driveroncogenes, thus far. Here, leveraging efforts from SOD model complexes,we report the novel finding of biomimetic copper complexes that efficientlyscavenge intracellularly generated free radicals and, thereby, directlyaccess the core consequence of colorectal cancer suppression. We conceivedfour structurally different SOD-mimicking copper complexes that showeddistinct disproportionation reaction rates of intracellular superoxideradical anions. By replenishing SOD models, we observed a dramaticreduction of intracellular reactive oxygen species (ROS) and adenine5 & PRIME;-triphosphate (ATP) concentrations that led to cell cyclearrest at the G2/M stage and induced apoptosis in vitro and in vivo.Our results showcase how nature-mimicking models can be designed andfine-tuned to serve as a viable chemotherapeutic strategy for cancertreatment.

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