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초록
In this work, we report that high-density, vertically grown silicon nanowires (vg-SiNWs) direct a new in vitro developmental pathway of primary hippocampal neurons. Neurons on vg-SiNWs formed a single, extremely elongated major neurite earlier than minor neurites, which led to accelerated polarization. Additionally, the development of lamellipodia, which generally occurs on 2D culture coverslips, was absent on vg-SiNWs. The results indicate that surface topography is an important factor that influences neuronal development and also provide implications for the role of topography in neuronal development in vivo.
키워드
Silicon nanowires; neurite development; F-actin dynamics; primary hippocampal neuron; chemical vapor deposition; live-cell imaging; NEURITE OUTGROWTH; HIPPOCAMPAL-NEURONS; ARRAYS; GROWTH; ACCELERATION; CYTOSKELETON; INTERFACES; DYNAMICS; PLATFORM; POLARITY
- 제목
- Axon-First Neuritogenesis on Vertical Nanowires
- 저자
- Kang, Kyungtae; Park, Yi-Seul; Park, Matthew; Jang, Min Jee; Kim, Seong-Min; Lee, Juno; Choi, Ji Yu; Jung, Da Hee; Chang, Young-Tae; Yoon, Myung-Han; Lee, Jin Seok; Nam, Yoonkey; Choi, Insung S.
- 발행일
- 2016-01
- 유형
- Article
- 저널명
- Nano Letters
- 권
- 16
- 호
- 1
- 페이지
- 675 ~ 680