파골세포 분화에 관여하는 phosphodiesterase isozyme의 규명

초록

Phosphodiesterases (PDEs) are enzymes that degrade intracellular cAMP and cGMP. In the present study, inhibition of PDE4 was demonstrated to influence osteoclast formation in co-cultures of mouse bone marrow cells and calvarial osteoblasts. Furthermore, PDE4 was shown to modulate mRNA expression of EP4, TRANCE, and COX-2 in calvarial osteoblasts. These results suggest that PDE4 is a key regulator of EP4, TRANCE, and COX-2 expression in osteoblasts, which in turn controls osteoclast formation.