GxG-Viztool: A program for visualizing gene-gene interactions in genetic association analysis

Kim, Kyunga; Kwon, Min-Seok; Lee,  Sung Young; Namkung, Junghyun; Li, Ming D; Park, Taesung

doi:10.1109/BIBMW.2012.6470249

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GxG-Viztool: A program for visualizing gene-gene interactions in genetic association analysis

Kim, Kyunga;
Kwon, Min-Seok;
Lee, Sung Young;
Namkung, Junghyun;
Li, Ming D;
외 1명

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초록

Gene-gene interactions are important factors underlying a common complex trait that is mostly polygenic. While many methods have been proposed to analyze gene-gene interactions in genetic association studies, the interpretation of the identified gene-gene interactions is not straightforward. In order to aid the interpretation of gene-gene interactions, we developed the GxG-Viztool, an executable program for visualizing gene-gene interactions in genetic association analysis. The GxG-Viztool provides an effective way to recognize genotype combinations that enhance/repress a trait and to display polygenic structure of interactions. The GxG-Viztool implements six graphical tools: checkerboard, pairwise checkerboard, forest, funnel, 3D lattice and parallel coordinate plots, which make it effective to recognize certain patterns in gene-gene interactions. It is freely available at http://bibs. snu. ac. kr/GxG-Viz tool. © 2012 IEEE.

키워드

Gene-gene interaction; Genetic association analysis; Pattern recognition; Visualization; 3D lattices; Association analysis; Complex traits; Executable programs; Gene-gene interaction; Graphical tools; Parallel coordinate plots; Association reactions; Bioinformatics; Flow visualization; Pattern recognition; Genes

제목: GxG-Viztool: A program for visualizing gene-gene interactions in genetic association analysis

저자: Kim, Kyunga; Kwon, Min-Seok; Lee, Sung Young; Namkung, Junghyun; Li, Ming D; Park, Taesung

DOI: 10.1109/BIBMW.2012.6470249

발행일: 2012-10

유형: Conference Paper

저널명: Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2012

페이지: 838 ~ 843

언어: ENG

출판사: IEEE

분량: 6 페이지

ISSN: P 0000-0000