상세 보기
- Lim, Eun-Ju;
- Kang, Hyun-Jung;
- Jung, Hyun-Joo;
- Song, Yun-Seon;
- Lim, Chang-Jin;
- 외 1명
WEB OF SCIENCE
32SCOPUS
32초록
The current study aimed to assess some novel pharmacological activities of vanillin. Vanillin inhibited the chick chorioallantoic membrane (CAM) angiogenesis. Vanillin had anti-inflammatory activity using the acetic acid-induced permeability model in mice. Anti-nociceptive activity of vanillin was shown using the acetic acid-induced writhing test in mice. Vanillin inhibited production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) but not cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. Vanillin decreased the level of iNOS mRNA in the LPS-activated macrophages. Taken together, these results suggest that vanillin can have anti-angiogenic, anti-inflammatory and anti-nociceptive activities in ICR Mice.
키워드
- 제목
- Anti-angiogenic, anti-inflammatory and anti-nociceptive activities of vanillin in ICR mice
- 저자
- Lim, Eun-Ju; Kang, Hyun-Jung; Jung, Hyun-Joo; Song, Yun-Seon; Lim, Chang-Jin; Park, Eun-Hee
- 발행일
- 2008-06
- 유형
- Article
- 권
- 16
- 호
- 2
- 페이지
- 132 ~ 136