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Nuclear receptors and coregulators in inflammation and cancer
- Lee, Jason S.;
- Kim, Keun Il;
- Baek, Sung Hee
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16초록
Functional role of nuclear receptors and numerous coregulators have been Studied in terms Of regulating transcriptional control of genes that play critical roles in various pathways. There is growing evidence that nuclear receptors and their coregulators control inflammatory programs of gene expression and progression of hormone-dependent cancer. This review provides a general overview of the interrelationship between nuclear receptor signalling, inflammation and cancer. These insights provide inflammatory genes as attractive targets for the development of cancer therapeutics. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
키워드
nuclear receptor; inflammation; cancer; NF-KAPPA-B; THYROID-HORMONE RECEPTOR; LIGAND-BINDING DOMAIN; PROSTATE-CANCER; ANDROGEN-RECEPTOR; ESTROGEN-RECEPTOR; GENE-EXPRESSION; RETINOIC ACID; MOLECULAR-MECHANISMS; BREAST-CANCER
- 제목
- Nuclear receptors and coregulators in inflammation and cancer
- 저자
- Lee, Jason S.; Kim, Keun Il; Baek, Sung Hee
- 발행일
- 2008-08
- 유형
- Review
- 저널명
- Cancer Letters
- 권
- 267
- 호
- 2
- 페이지
- 189 ~ 196