상세 보기
- Yoo, Kyung Hyun;
- Lee, Tae Young;
- Yang, Moon Hee;
- Park, Eun Young;
- Yook, Yeon Joo;
- 외 2명
WEB OF SCIENCE
3SCOPUS
3초록
ADPKD (Autosomal Dominant Polycystic Kidney Disease) is characterized by the progressive expansion Of Multiple cystic lesions in the kidneys. ADPKD is caused by mutations in Ed-pl. consider PKD1 and PKD2. Recently a relation between c-myc and the pathogenesis of ADPKD was reported. in addition, c-Myc is a downstream effector of PKD1. To identify the gene regulated by PKD2 and c-Myc, we performed gene expression profiling in PKD2 and c-Myc overexpressing cells using a human 8K cDNA microarray. NCAM (neuronal cell adhesion molecule) levels were significantly reduced in PKD2 overexpressing systems in vitro and in vivo. These results suggest that NCAM is an important molecule in the cystogenesis induced by PKD2 overexpession.
키워드
- 제목
- NCAM as a cystogenesis marker gene of PKD2 overexpression
- 저자
- Yoo, Kyung Hyun; Lee, Tae Young; Yang, Moon Hee; Park, Eun Young; Yook, Yeon Joo; Lee, Hyo Soo; Park, Jong Hoon
- 발행일
- 2008-08
- 유형
- Article
- 저널명
- BMB Reports
- 권
- 41
- 호
- 8
- 페이지
- 593 ~ 596