ScholarWorks@숙명여자대학교

초록

Pectolinarin and pectolinarigenin have been reported to be major compounds in Cirsium setidens. In the present study, we demonstrated inhibitory effects of pectolinarin and pectolinarigenin from C. setidens on melanogenesis. Melanin synthesis was decreased in both pectolinarin- and pectolinarigenin-treated melan-a cells and in a reconstructed human skin model. However, pectolinarigenin treatment showed more potent inhibitory activity of melanin synthesis than did pectolinarin treatment. The concentrations of pectolinarin and pectolinarigenin in C setidens water extracts were determined by HPLC. Unfortunately, the amount of pectolinarigenin of C setidens water extract was lower than that of pectolinarin. To increase the pectolinarigenin content in C setidens water extract, several component conversion methods were studied. Consequently, we identified that microwave irradiation under 1% acetic acid was an optimum sugar elimination method. (C) 2017 Elsevier Inc. All rights reserved.

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