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Cigarette smoke impairs the hematopoietic supportive property of mesenchymal stem cells via the production of reactive oxygen species and NLRP3 activation
- Park, Hyun Sung;
- Lee, Byung-Chul;
- Chae, Dong-Hoon;
- Yu, Aaron;
- Park, Jae Han;
- 외 8명
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16Citations
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16초록
Mesenchymal stem cells (MSCs) play important roles in tissue homeostasis by providing a supportive microenvironmental niche for the hematopoietic system. Cigarette smoking induces systemic abnormalities, including an impeded recovery process after hematopoietic stem cell transplantation. However, the role of cigarette smoking-mediated alterations in MSC niche function have not been investigated.
키워드
Bone marrow niche; Cigarette smoking extract; Mesenchymal stem cells; NLRP3; Reactive oxygen species; STROMAL CELLS; EXPOSURE; TRANSPLANTATION; PROLIFERATION; INFLAMMATION; NICOTINE; OUTCOMES
- 제목
- Cigarette smoke impairs the hematopoietic supportive property of mesenchymal stem cells via the production of reactive oxygen species and NLRP3 activation
- 저자
- Park, Hyun Sung; Lee, Byung-Chul; Chae, Dong-Hoon; Yu, Aaron; Park, Jae Han; Heo, Jiyoung; Han, Myoung Hee; Cho, Keonwoo; Lee, Joong Won; Jung, Ji-Won; Dunbar, Cynthia E.; Oh, Mi-Kyung; Yu, Kyung-Rok
- 발행일
- 2024-05
- 유형
- Article
- 권
- 15
- 호
- 1
- 언어
- ENG
- 출판사
- BioMed Central
- 발행국가
- 영국
- ISSN
- E 1757-6512
P 1757-6512