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초록
This study was performed to investigate the potential of pear (Pyrus pyrifolia) as a immune-modulating functional food by assay of splenocytes proliferation and induction of cytokines (IFN-g, IL-4) in vitro. When mouse splenocytes were exposed to various concentration (0.16, 0.31, 0.63, 1.25, 2.50 mg/ml) of pear methanol extracts (P-M) without mitogens, splenocytes proliferation (SP) was significantly increased. Also, SP to mitogens, concanavalin A (Con A) and lipopolysaccharide (LPS) were significantly increased by P-M when compared with controls. When splenocytes were cultured with P-M in the presence of Con A, cytokine (IFN-g, IL-4) levels in culture supernatant were significantly enhanced in a dose-dependent manner except 2.5 mg/ml when compared with control group. Therefore, our study suggest that the pear has the potential of being an immune-modulating functional food.
키워드
- 제목
- 배의 메탄올 추출물이 마우스의 비장세포 증식능과 Cytokine 생성능에 미치는 영향
- 제목 (타언어)
- Effects of Pear (Pyrus pyrifolia) Methanol Extracts on the Proliferation and the Cytokines Productionof Mouse Splenocytes
- 저자
- 황유경; 표명윤
- 발행일
- 2005-02
- 저널명
- 약 학 회 지
- 권
- 49
- 호
- 1
- 페이지
- 25 ~ 29