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Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages
- Jin, Guo Hua;
- Lee, Hwa Jin;
- Gim, Hyo Jin;
- Ryu, Jae-Ha;
- Jeon, Raok
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Series of carbamate and thiocarbamate derivatives were designed and synthesized and their inhibitory activities of NO production in lipopolysaccharide-activated macrophages were evaluated. Several thoicarbamate derivatives revealed promising inhibitory activity. The structure-activity relationship study of these compounds is also reported. Among these compounds, compound 12b was the most potent with 6.5 mu M of IC50. They inhibited NO production through the suppression of iNOS protein and mRNA expression and nuclear translocation of p65. (C) 2012 Elsevier Ltd. All rights reserved.
키워드
Carbamate; Thiocarbamate; Nitric oxide; iNOS; NITRIC-OXIDE SYNTHASE
- 제목
- Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages
- 저자
- Jin, Guo Hua; Lee, Hwa Jin; Gim, Hyo Jin; Ryu, Jae-Ha; Jeon, Raok
- 발행일
- 2012-05-01
- 유형
- Article
- 권
- 22
- 호
- 9
- 페이지
- 3301 ~ 3304