상세 보기
Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases
- Houh, Youn Kyung;
- Kim, Kyung Eun;
- Park, Hyun Jeong;
- Cho, Daeho
Citations
WEB OF SCIENCE
12Citations
SCOPUS
15초록
Erythroid Differentiation Regulator 1 (Erdr1) is known as a hemoglobin synthesis factor which also regulates cell survival under conditions of stress. In addition, previous studies have revealed the effects of Erdr1 on cancer progression and its negative correlation with interleukin (IL)-18, a pro-inflammatory cytokine. Based on this evidence, the therapeutic effects of Erdr1 have been demonstrated in several inflammatory skin diseases such as malignant skin cancer, psoriasis, and rosacea. This article reviews the roles of Erdr1 in skin inflammation, suggesting that Erdr1 is a potential therapeutic molecule on inflammatory disorders.
키워드
Erdr1; IL-18; cutaneous inflammation; melanoma; psoriasis; rosacea; CELL IMMUNE SYNAPSE; MELANOMA METASTASIS; DOWN-REGULATION; IFN-GAMMA; T-CELLS; PSORIASIS; IL-18; CANCER; ROSACEA; PATHOGENESIS
- 제목
- Roles of Erythroid Differentiation Regulator 1 (Erdr1) on Inflammatory Skin Diseases
- 저자
- Houh, Youn Kyung; Kim, Kyung Eun; Park, Hyun Jeong; Cho, Daeho
- 발행일
- 2016-12
- 유형
- Review
- 권
- 17
- 호
- 12
- 페이지
- 1 ~ 10
- 언어
- ENG
- 출판사
- MDPI
- 발행국가
- 스위스
- 분량
- 10 페이지
- ISSN
- E 1422-0067
P 1661-6596