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초록
The cytotoxic effect of iron was examined in peritoneal macrophage to determine contributing factors by iron injection to rat. Viability was reduced by 24% by the iron-overload and by 30% by short-term iron addition. Total iron was increased by 45% in the iron-overloaded with remarkable elevation (9 to 14 fold) in the presence of FeSO4 . Free calcium was also increased by 19% in control and 44% in iron-overloaded group due to additional FeSO4 . NO and MDA were increased by 40% and 136%, respectively, with significant reduction (37%) of NAD(P)H. RCR and cytochrome c oxidase activity were lowered approximately by 10% with reduction of mitochondrial membrane potential. Addition of iron was frequently associated with altered distribution of mitochondria of high membrane potential in the iron-overloaded macrophage. These results suggest altered mitochondria with high NO and low NAD(P)H due to iron.
키워드
- 제목
- Iron Toxicity to Peritoneal Macrophage Due to Alteration of Mitochondria by NO
- 제목 (타언어)
- Iron Toxicity to Peritoneal Macrophage Due to Alteration of Mitochondria by NO
- 저자
- Ji-yeon Yoon; Jinsun Kim; Heum-Sook Lee; Kyo-Young Lee; 천충일; 이명석; Jong Hoon Park; Eunsook Song
- 발행일
- 2004-06
- 권
- 8
- 호
- 2
- 페이지
- 97 ~ 103