ScholarWorks@숙명여자대학교

초록

The clinical use of once daily aminoglycoside (ODA) dosing has been increased because of the poten-tial therapeutic advantages of this dosing regimen. To evaluate the optimal sampling times of ODA dosing methodin a clinical setting, the study was prospectively conducted in a total of 28 patients with UTI. All of the patientswere intravenously administered gentamicin at a dose of 7 mg/kg over 60 minutes and randomly divided into twogroups. Blood was collected at 0, 2, and 6 hours in Group A and at 1, 2, and 6 hours in Group B after the end of 1-hour infusion. The pharmacokinetic parameters (Ke, Vd and Cmax) obtained using the 0, 6 hour levels and 2, 6hour levels in Group A were statistically different while those of 1, 6 hour levels and 2, 6 hour levels in Group Bwere similar. This finding indicated that the distributional phase of ODA is completed within 1 hour following theend of the 1-hour infusion. If we are allowed to collect only two blood samples in ODA considering patients com-fort and the analytical cost of drug, the first one should be drawn after 1 hour following the end of infusion toobtain adequate pharmacokinetic information.Keywords□ once daily gentamicin, optimal sampling times, pharmacokinetic parameter