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초록
n-Propyl gallate dose-dependently displayed an inhibitory effect on chick chorioallantoic membrane (CAM) angiogenesis. It markedly increased the endostatin level in both isolated CAM tissues and human umbilical vein endothelial cells (HUVECs). n-Propyl gallate was also able to enhance the endostatin mRNA level in HUVECs. Antinociceptive activity of n-propyl gallate was assessed using an acetic acid-induced writhing test in mice. In brief, n-propyl gallate possesses antiangiogenic activity via up-regulation of endostatin. Copyright (C) 2011 John Wiley & Sons, Ltd.
키워드
n-propyl gallate; antiangiogenic; endostatin; antinociceptive; chorioallantoic membrane; ANGIOGENESIS INHIBITOR; HELA-CELLS; ENDOSTATIN; GROWTH; ARTHRITIS
- 제목
- The Antiangiogenic and Antinociceptive Activities of n-Propyl Gallate
- 저자
- Jung, H-J.; Lim, C-J.
- DOI
- 10.1002/ptr.3452
- 발행일
- 2011-10
- 유형
- Article
- 권
- 25
- 호
- 10
- 페이지
- 1570 ~ 1573