상세 보기
- Lee, S. H.;
- Kim, K-Y;
- Ryu, S. Y.;
- Yoon, Y.;
- Hahm, D-H;
- ... Yang, Y.;
- 외 7명
WEB OF SCIENCE
14SCOPUS
24초록
Asarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-alpha and peroxisome proliferator activated receptor-gamma, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPAR gamma and C/EBP alpha and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity.
키워드
- 제목
- ASARONE INHIBITS ADIPOGENESIS AND STIMULATES LIPOLYSIS IN 3T3-L1 ADIPOCYTES
- 저자
- Lee, S. H.; Kim, K-Y; Ryu, S. Y.; Yoon, Y.; Hahm, D-H; Kang, S. A.; Cho, S. H.; Lim, J-S; Moon, E-Y; Yoon, S. R.; Lee, H. G.; Yoon, D. Y.; Yang, Y.
- DOI
- 10.1170/138
- 발행일
- 2010-01
- 유형
- Article
- 권
- 56
- 페이지
- OL1215 ~ OL1222