ASARONE INHIBITS ADIPOGENESIS AND STIMULATES LIPOLYSIS IN 3T3-L1 ADIPOCYTES

Lee, S. H.; Kim, K-Y; Ryu, S. Y.; Yoon, Y.; Hahm, D-H; Kang, S. A.; Cho, S. H.; Lim, J-S; Moon, E-Y; Yoon, S. R.; Lee, H. G.; Yoon, D. Y.; Yang, Y.

doi:10.1170/138

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ASARONE INHIBITS ADIPOGENESIS AND STIMULATES LIPOLYSIS IN 3T3-L1 ADIPOCYTES

Lee, S. H.;
Kim, K-Y;
Ryu, S. Y.;
Yoon, Y.;
Hahm, D-H;
... Yang, Y.;
외 7명

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14

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24

초록

Asarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-alpha and peroxisome proliferator activated receptor-gamma, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPAR gamma and C/EBP alpha and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity.

키워드

C/EBP alpha; PPAR gamma; Adiponectin; Asarone; Hormone-sensitive lipase; HORMONE-SENSITIVE LIPASE; ADIPOSE TRIGLYCERIDE LIPASE; FATTY-ACID OXIDATION; RESVERATROL; APOPTOSIS; KINASE

제목: ASARONE INHIBITS ADIPOGENESIS AND STIMULATES LIPOLYSIS IN 3T3-L1 ADIPOCYTES

저자: Lee, S. H.; Kim, K-Y; Ryu, S. Y.; Yoon, Y.; Hahm, D-H; Kang, S. A.; Cho, S. H.; Lim, J-S; Moon, E-Y; Yoon, S. R.; Lee, H. G.; Yoon, D. Y.; Yang, Y.

DOI: 10.1170/138

발행일: 2010-01

유형: Article

저널명: Cellular and Molecular Biology

권: 56

페이지: OL1215 ~ OL1222

언어: ENG

출판사: C M B ASSOC

발행국가: 프랑스

ISSN: E 1165-158X
P 0145-5680