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초록
The ethyl acetate fraction of Gardenia jasminoides fruit (GJF) showed S-phase arrest of cell cycle in pancreatic cancer PANC-1 cells. GJF also reduced the levels of cell cycle regulatory proteins, such as cyclin B1, cyclin D1, and FoxM1, in PANC-1 cells and suppressed cell viability. Furthermore, the cell viability of PANC-1 cells was reduced by geniposide and 4,5-dicaffeoylquinic acid, which were detected in GJF by HPLC analysis. These results suggested that GJF has anti-proliferative activity via cell cycle arrest and regulation of cell cycle-related proteins in PANC-1 pancreatic cancer cells, and these effects of GJF might be partially attributed to geniposide and 4,5-dicaffeoylquinic acid.
키워드
Gardenia jasminoides; cell cycle arrest; pancreatic cancer; polyphenol
- 제목
- 췌장암 세포에서 치자나무 열매의 세포주기 정지 및 활성 성분의 세포증식억제
- 제목 (타언어)
- Cell cycle arrest by Gardenia jasminoides fruit and anti-proliferative activity by its active components in pancreatic cancer PANC-1 cells
- 저자
- 정지혜; 이화진
- 발행일
- 2022-10
- 저널명
- 한국식품과학회지
- 권
- 54
- 호
- 5
- 페이지
- 555 ~ 560