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초록
Clusterin (CLU) is known as a multifunctional protein involved in a variety of physiological processes including lipid transport, epithelial cell differentiation, tumorigenesis, and apoptosis. It is known that CLU interacts with TGF-beta type 11 receptor (T beta R11). However, the relationship of CLU and TGF-beta signaling is unclear. Here we present that CLU is a novel modulator of TGF-beta signaling by regulating Smad2/3 proteins. Overexpression of CLU enhanced TGF-beta-induced transcriptional activity and increased the amount of Smad2/3 proteins, while CLU siRNA repressed TGF-beta-induced transcriptional activity and decreased the amount of Smad2/3 proteins in Hep3B cells. We also found that CLU was involved in Smad2/3 stability at the protein level. These findings suggest that CLU regulates TGF-beta signaling pathway by modulating the stability of Smad2/3 proteins. (c) 2007 Elsevier Inc. All rights reserved.
키워드
- 제목
- Clusterin, a novel modulator of TGF-beta signaling, is involved in Smad2/3 stability
- 저자
- Lee, Kwan-Bok; Jeon, Jun-Ho; Choi, Inpyo; Kwon, O-Yu; Yu, Kweon; You, Kwan-Hee
- 발행일
- 2008-02-22
- 유형
- Article
- 권
- 366
- 호
- 4
- 페이지
- 905 ~ 909