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Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium
- Yoon, Jeong Hoon;
- Lim, Hyo Jin;
- Lee, Hwa Jin;
- Kim, Hee-Doo;
- Jeon, Raok;
- 외 1명
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51초록
Three sesquiterpenoids, xanthatin (1), xanthinosin (2), and 4-oxo-bedfordia acid (3) were isolated from Xanthium strumarium as inhibitors of nitric oxide synthesis in activated microglia (IC50 values: 0.47, 11.2, 136.5 mu M, respectively). Compounds 1 and 2 suppressed the expression of iNOS and COX-2 and the activity of NF-kappa B through the inhibition of LPS-induced I-kappa B-alpha degradation in microglia. (C) 2008 Elsevier Ltd. All rights reserved.
키워드
nitric oxide synthase; cyclooxygenase; Xanthium strumarium; sesquiterpene; nuclear factor kappa B; RAW 264.7 MACROPHAGES; INFLAMMATORY RESPONSE; INTERFERON-GAMMA; NERVOUS-SYSTEM; BIOSYNTHESIS; DISEASES; BRAIN; STRATEGIES; MICROGLIA; INJURY
- 제목
- Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium
- 저자
- Yoon, Jeong Hoon; Lim, Hyo Jin; Lee, Hwa Jin; Kim, Hee-Doo; Jeon, Raok; Ryu, Jae-Ha
- 발행일
- 2008-03-15
- 유형
- Article
- 권
- 18
- 호
- 6
- 페이지
- 2179 ~ 2182
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- E 1464-3405
P 0960-894X