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Synthesis of Quinoline-Indole Hybrids through Cu(II)-Catalyzed Amination and Annulation between <i>N</i>-Oxides and <i>o</i>-Alkynylanilines
- Rakshit, Amitava;
- Moon, Kyeongwon;
- Singh, Pargat;
- Park, Jung Su;
- Kim, In Su
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8초록
The synthesis of (iso)quinoline-indole hybrids by reacting (iso)quinoline N-oxides with o-alkynylanilines in the presence of a combination of copper(II) catalyst and a bidentate 2,2 '-bipyridine ligand is described. The utility of this method was demonstrated through site-selective functionalization of the synthesized products. A plausible reaction pathway for site-selective amination followed by annulative indole formation was elucidated by a series of mechanistic investigations.
키워드
CROSS-COUPLING REACTIONS; BOND FORMATION; C-N; CASCADE ANNULATION; H ACTIVATION; PALLADIUM
- 제목
- Synthesis of Quinoline-Indole Hybrids through Cu(II)-Catalyzed Amination and Annulation between <i>N</i>-Oxides and <i>o</i>-Alkynylanilines
- 저자
- Rakshit, Amitava; Moon, Kyeongwon; Singh, Pargat; Park, Jung Su; Kim, In Su
- 발행일
- 2024-12
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 26
- 호
- 51
- 페이지
- 11218 ~ 11223