ScholarWorks@숙명여자대학교

초록

Polygonum cuspidatum has been used as treatments of dermatitis, gonorhea, inflammation, and hyperlip-idaemia in traditional medicine. We examined liver protective effect on CCl4 inducing hepatotoxicity, and anti-oxidative activ-ity by TBA method. Phytochemical examination of Polygonum cuspidatum led to the isolation and characterization of emodin8-O-β-D-glucopyranoside (compound 1), and trans-resveratrol 3-O-β-D-glucopyranoside (compound 2). Compounds 1 and2 enhanced the inhibition of anti-lipid peroxidative effects in liver homogenate. In chemical parameters obtained from serumanalysis, compounds 1 and 2 also revealed significant decrease in hepatotoxicity. These results suggested that theantraquinone and stilbene which were isolated from Polygonum cuspidatum might be used as therapeutic agent of hepatitis.Keywords . Polygonum cuspidatum, emodin 8-O-β-D-glucopyranoside, trans-resveratrol 3-O-β-D-glucopyranoside, hepa-toxicity.. (Polygonum cuspidatum Sied. et Zucc.). ....(Polygonaceae). ... ... .... .... .. , .. ,.. . ... ... , ... , ... .. ..1). ...... . ... .. .... Yang et al.2). resveratrol. anth-raglycoside, Zhao et al.3). emodin, resveratrol, polydatin,Matsuda et al.4). hydroxyanthraquinons, Xiao et al.5). stilbeneglycoside sulfates .. .. ..... . ....... .... ,6) acyl-coenzyme A-cholesterol acyltransferase .. ,7)Helicobacter pylori ...... ,8) In vitro... ... ......... ,9) kinase inhibitor... .. ,10) Emodin. NF-κB ...... ,11) ..... ,12,13) .. ...... ,14) ....15) . ..... ....16) .. ... . .. .

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