상세 보기
- Park, Hyojung;
- No, A. Long Sae Mi;
- Lee, Jung-Min;
- Chen, Ling;
- Lee, Soo Young;
- ... Yim, Mijung;
- 외 1명
WEB OF SCIENCE
12SCOPUS
14초록
We investigated the interplay between parathyroid hormone (PTH) and phosphodiesterases (PDEs) in osteoblasts. PDE4 negatively regulated PTH-induced cAMP accumulation. PDE4 inhibitor enhanced PTH-induced osteoclast formation and RANKL mRNA expression, which is partially mediated by COX-2 mRNA expression. Two CRE sites in the COX-2 promoter were required for the increase in COX-2 transcription by PDE4 inhibitor, and the expression of a dominant-negative form of CREB abolished COX-2 mRNA expression in response to PDE4 inhibitor or PTH in osteoblasts. Taken together, our data indicate that PDE4 inhibitor promotes PTH-induced osteoclast formation partially via CRE-mediated COX-2 mRNA expression. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
키워드
- 제목
- PDE4 inhibitor upregulates PTH-induced osteoclast formation via CRE-mediated COX-2 expression in osteoblasts
- 저자
- Park, Hyojung; No, A. Long Sae Mi; Lee, Jung-Min; Chen, Ling; Lee, Soo Young; Lee, Dong-Seok; Yim, Mijung
- 발행일
- 2010-01-04
- 유형
- Article
- 저널명
- FEBS Letters
- 권
- 584
- 호
- 1
- 페이지
- 173 ~ 180