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초록
Annexin-1 (ANX1) is an anti-inflammatory protein as well as an important modulator in inflammation. However, the precise action of ANX1 remains unclear. To elucidate the protective effects of ANX1 on lipopolysaccharide (LPS)-induced murine macrophage Raw 264.7 cells, we constructed a cell-permeable Tat-ANX1 protein. The transduced Tat-ANX1 protein markedly inhibited the expression of cyclooxygenase-2, production of prostaglandin E-2, and generation of pro-inflammatory cytokines in the cells. Furthermore, transduced Tat-ANX1 protein caused a significant reduction in the activation of nuclear factor-kappa B (NF-kappa B) and mitogen-activated protein kinase (MAPK). The results indicate that Tat-ANX1 inhibits the production of inflammatory response cytokines and enzymes by blocking NF-kappa B and MAPK. Therefore, Tat-ANX1 protein may be useful as a therapeutic agent against various inflammatory diseases. [BMB reports 2011; 44(7): 484-489]
키워드
- 제목
- Transduced Tat-Annexin protein suppresses inflammation-associated gene expression in lipopolysaccharide (LPS)-stimulated Raw 264.7 cells
- 저자
- Lee, Sun Hwa; Kim, Dae Won; Back, Su Sun; Hwang, Hyun Sook; Park, Eun Young; Kang, Tae-Cheon; Kwon, Oh-Shin; Park, Jong Hoon; Cho, Sung-Woo; Han, Kyu Hyung; Park, Jinseu; Eum, Won Sik; Choi, Soo Young
- 발행일
- 2011-07
- 유형
- Article
- 저널명
- BMB Reports
- 권
- 44
- 호
- 7
- 페이지
- 484 ~ 489