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PPAR의 리간드로서 새로운 요소 유도체의 분자설계 및 합성
Design and Synthesis of Novel Urea Analog as a PPAR ligand
- 김윤정;
- 전라옥
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0초록
PPAR is one of the significant drug targets and activation of PPAR □ by several thiazolidinedione derivatives is well established. Herein bioisosteric replacement of thiazolidinedione to urea was carried out. Non-thiazolidinedione derivatives, [4-(2-carbazol-9-ylethoxy)phenyl]ureas (5, 6) were designed and synthesized to obtain novel PPAR activators.
- 제목
- PPAR의 리간드로서 새로운 요소 유도체의 분자설계 및 합성
- 제목 (타언어)
- Design and Synthesis of Novel Urea Analog as a PPAR ligand
- 저자
- 김윤정; 전라옥
- 발행일
- 2006-02
- 저널명
- 약학논문집-숙명여자대학교
- 권
- 23
- 페이지
- 50 ~ 54