잔류용매 제거를 통한 신경전극의 생체적합성 향상

초록

To enhance biocompatibility of neural electrode, residual solvent in the neural electrode was reduced by solvent extraction and ultra-sonication processes. The solvent-extracted polyimide (PI) films are subcutaneously implanted in the mouse. The biocompatibility of the PI film was analyzed using the cytotoxicity, RT-PCR, and H & E staining. The solvent-extracted PI film shows better short term biocompatible characteristics over control and non-treated PI film. This solvent reduction method can be used to increase the biocompatibility of neural electrode.