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Efficient Synthesis and Characterization of Monoprotected Symmetrical Poly(Ethylene Glycol) Diamine
- Jeong, Hyeri;
- Youn, Dayoung;
- Nam, Jihye;
- Kim, Jaehi;
- Lee, Yoon-Sik;
- ... Shin, Dong-Sik
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4초록
Solid-phase synthesis of monoprotected poly(ethylene glycol) (PEG) diamine is demonstrated. 2-Chlorotrityl chloride (2-CTC) resin was used as a solid support for inducing monofunctionalization using excess PEG diamine. Fmoc-monoprotected PEG was prepared from 2-CTC resin and fully characterized by high-performance liquid chromatography and electrospray ionization mass spectrometry. We envision that this strategy will provide an efficient method of preparing various kinds of heterobifunctional PEG molecules without a need for further purification steps.
키워드
Monofunctionalization; Solid-phase synthesis; 2-Chlorotrityl chloride resin; Poly(ethylene glycol); Fmoc group; 2-CHLOROTRITYL RESIN; PEPTIDE; DELIVERY; FMOC; PEG
- 제목
- Efficient Synthesis and Characterization of Monoprotected Symmetrical Poly(Ethylene Glycol) Diamine
- 저자
- Jeong, Hyeri; Youn, Dayoung; Nam, Jihye; Kim, Jaehi; Lee, Yoon-Sik; Shin, Dong-Sik
- 발행일
- 2017-12
- 유형
- Article
- 권
- 39
- 호
- 1
- 페이지
- 29 ~ 32