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PEG grafted AM SURE (TM) resin and its application to solid-phase peptide synthesis
- Kim, Mira;
- Park, Yong-Sun;
- Shin, Dong-Sik;
- Lee, Song;
- Lee, Yoon-Sik
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3초록
PEGylated core-shell type resin (PEG-AM SURE) was developed by modifying the surface of AM SURE (TM) resin with diamino PEG. The conditions for the PEG coupling reaction were optimized by adjusting PEG chain cross-linking and the amount of free amino groups to ensure a enough loading level of functional groups on the resin (>0.30-0.39 mmol NH2/g). The resulting PEG-AM SURE resin showed better performance than conventional resins during solid-phase peptide synthesis of JR10-mer and beta 2m(58-69) 12-mer. (C) 2012 Elsevier Ltd. All rights reserved.
키워드
Core-shell type resin bead; Polymer support; Solid-phase peptide synthesis; ORGANIC-REACTIONS; DIFFICULT SEQUENCE; BOP
- 제목
- PEG grafted AM SURE (TM) resin and its application to solid-phase peptide synthesis
- 저자
- Kim, Mira; Park, Yong-Sun; Shin, Dong-Sik; Lee, Song; Lee, Yoon-Sik
- 발행일
- 2012-08
- 권
- 53
- 호
- 34
- 페이지
- 4576 ~ 4579
- 언어
- ENG
- 출판사
- PERGAMON-ELSEVIER SCIENCE LTD
- 발행국가
- 네덜란드
- 분량
- 4 페이지
- ISSN
- P 0040-4039