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초록
B7-H4 has an inhibitory effect on immune responses via the down-regulation of T cell-mediated immunity, but how the engagement of B7-H4 molecules by counter molecules affects the signaling mechanism of the B7-H4-expressing cells is poorly defined. In this study, we found that B7-H4 expression was enhanced on B cells infected with Epstein-Barr virus (EBV) and that triggering of these molecules induced apoptosis of EBV-transformed B cells. Engagement of B7-H4 initially increased intracellular level of ROS, which then induced the expression of FasL. Engagement of B7-H4 subsequently provoked Fas-mediated and caspase-dependent apoptosis in association with cytochrome e and AIF, and EndoG was released from the mitochondria on EBV-transformed B cells. These results suggest that B7-H4 may be a potential therapeutic target for EBV involved malignancy diseases. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
키워드
- 제목
- B7-H4 reverse signaling induces the apoptosis of EBV-transformed B cells through Fas ligand up-regulation
- 저자
- Song, Hyunkeun; Park, Gabin; Kim, Yeong-Seok; Hur, Indo; Kim, Hyunjin; Ryu, Jeoung Whan; Lee, Hyun-Kyung; Cho, Dae-Ho; Choi, In-Hak; Lee, Wang Jae; Hur, Dae Young
- 발행일
- 2008-08-08
- 유형
- Article
- 저널명
- Cancer Letters
- 권
- 266
- 호
- 2
- 페이지
- 227 ~ 237