Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis
DC Field | Value | Language |
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dc.contributor.author | Mongre, Raj Kumar | - |
dc.contributor.author | Mishra, Chandra Bhushan | - |
dc.contributor.author | Jung, Samil | - |
dc.contributor.author | Lee, Beom Suk | - |
dc.contributor.author | Quynh, Nguyen Thi Ngoc | - |
dc.contributor.author | Anh, Nguyen Hai | - |
dc.contributor.author | Myagmarjav, Davaajragal | - |
dc.contributor.author | Jo, Taeyeon | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.date.available | 2021-02-22T04:57:18Z | - |
dc.date.issued | 2020-12 | - |
dc.identifier.issn | 2372-7705 | - |
dc.identifier.issn | 2372-7705 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/1001 | - |
dc.description.abstract | TRIP-Brs, a group of transcription factors (TFs) that modulate several mechanisms in higher organisms. However, the novel paradigm to target TRIP-Brs in specific cancer remains to be deciphered. In particular, comprehensive analysis of TRIP-Brs in clinicopathological and patients’ prognosis, especially in breast cancer (BRCA), is being greatly ignored. Therefore, we explored the key roles of TRIP-Br expression, modulatory effects, mutations, immune infiltration, and prognosis in BRCA using multidimensional approaches. We found elevated levels of TRIP-Brs in numerous cancer tissues than normal. Higher expression of TRIP-Br-2/4/5 was shown to be positively associated with lower survival, tumor grade, and malignancy of patients with BRCA. Additionally, higher TRIP-Br-3/4 were also significantly linked with worse/short survival of BRCA patients. TRIP-Br-1/4/5 were significantly overexpressed and enhanced tumorigenesis in large-scale BRCA datasets. The mRNA levels of TRIP-Brs have been also correlated with tumor immune infiltrate in BRCA patients. In addition, TRIP-Brs synergistically play a pivotal role in central carbon metabolism, cancer-associated pathways, cell cycle, and thyroid hormone signaling, which evoke that TRIP-Brs may be a potential target for the therapy of BRCA. Thus, this investigation may lay a foundation for further research on TRIP-Br-mediated management of BRCA. © 2020 The AuthorsHigher expression of TRIP-Brs was observed in breast cancer patients via modulating the multiple signaling pathways associated with the fate of cancer cells. Higher expression of TRIP-Brs was positively associated with lower survival, tumor grade, and malignancy of BRCA patients. TRIP-Brs appeared as valuable biomarkers for prognosis of breast cancer. © 2020 The Authors | - |
dc.format.extent | 22 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Cell Press | - |
dc.title | Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.omto.2020.09.003 | - |
dc.identifier.scopusid | 2-s2.0-85091941946 | - |
dc.identifier.wosid | 000600047100010 | - |
dc.identifier.bibliographicCitation | Molecular Therapy - Oncolytics, v.19, pp 105 - 126 | - |
dc.citation.title | Molecular Therapy - Oncolytics | - |
dc.citation.volume | 19 | - |
dc.citation.startPage | 105 | - |
dc.citation.endPage | 126 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | biological marker | - |
dc.subject.keywordPlus | messenger RNA | - |
dc.subject.keywordPlus | STAT3 protein | - |
dc.subject.keywordPlus | thyroid hormone | - |
dc.subject.keywordPlus | transcription factor | - |
dc.subject.keywordPlus | transcription factor TRIP Br | - |
dc.subject.keywordPlus | transcription factor TRIP Br 1 | - |
dc.subject.keywordPlus | transcription factor TRIP Br 2 | - |
dc.subject.keywordPlus | transcription factor TRIP Br 3 | - |
dc.subject.keywordPlus | transcription factor TRIP Br 4 | - |
dc.subject.keywordPlus | transcription factor TRIP Br 5 | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | animal experiment | - |
dc.subject.keywordPlus | animal model | - |
dc.subject.keywordPlus | animal tissue | - |
dc.subject.keywordPlus | Article | - |
dc.subject.keywordPlus | B lymphocyte | - |
dc.subject.keywordPlus | breast cancer | - |
dc.subject.keywordPlus | breast cancer cell line | - |
dc.subject.keywordPlus | breast carcinogenesis | - |
dc.subject.keywordPlus | breast carcinoma | - |
dc.subject.keywordPlus | breast tissue | - |
dc.subject.keywordPlus | cancer grading | - |
dc.subject.keywordPlus | cancer prognosis | - |
dc.subject.keywordPlus | cancer staging | - |
dc.subject.keywordPlus | cancer tissue | - |
dc.subject.keywordPlus | carbon metabolism | - |
dc.subject.keywordPlus | CD4+ T lymphocyte | - |
dc.subject.keywordPlus | CD8+ T lymphocyte | - |
dc.subject.keywordPlus | cell infiltration | - |
dc.subject.keywordPlus | clinical feature | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | copy number variation | - |
dc.subject.keywordPlus | dendritic cell | - |
dc.subject.keywordPlus | disease free survival | - |
dc.subject.keywordPlus | disease specific survival | - |
dc.subject.keywordPlus | distant metastasis free survival | - |
dc.subject.keywordPlus | down regulation | - |
dc.subject.keywordPlus | estrogen receptor positive breast cancer | - |
dc.subject.keywordPlus | gene ontology | - |
dc.subject.keywordPlus | gene overexpression | - |
dc.subject.keywordPlus | histopathology | - |
dc.subject.keywordPlus | human | - |
dc.subject.keywordPlus | human cell | - |
dc.subject.keywordPlus | immunocompetent cell | - |
dc.subject.keywordPlus | in vitro study | - |
dc.subject.keywordPlus | in vivo study | - |
dc.subject.keywordPlus | lobular carcinoma | - |
dc.subject.keywordPlus | luminal A breast cancer | - |
dc.subject.keywordPlus | luminal B breast cancer | - |
dc.subject.keywordPlus | macrophage | - |
dc.subject.keywordPlus | missense mutation | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | mRNA expression level | - |
dc.subject.keywordPlus | neutrophil | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | overall survival | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | protein function | - |
dc.subject.keywordPlus | recurrence free survival | - |
dc.subject.keywordPlus | signal transduction | - |
dc.subject.keywordPlus | triple negative breast cancer | - |
dc.subject.keywordPlus | upregulation | - |
dc.subject.keywordAuthor | BRCA | - |
dc.subject.keywordAuthor | clinicopathological | - |
dc.subject.keywordAuthor | KEGG pathways | - |
dc.subject.keywordAuthor | mutation | - |
dc.subject.keywordAuthor | patient survival | - |
dc.subject.keywordAuthor | transcription factors | - |
dc.subject.keywordAuthor | TRIP-Brs | - |
dc.subject.keywordAuthor | tumor-infiltrating immune cells | - |
dc.identifier.url | https://www.cell.com/molecular-therapy-family/oncolytics/fulltext/S2372-7705(20)30140-6?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2372770520301406%3Fshowall%3Dtrue | - |
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