Clinical Correlates of Mass Effect in Autosomal Dominant Polycystic Kidney Disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Hyunsuk | - |
dc.contributor.author | Park, Hayne Cho | - |
dc.contributor.author | Ryu, Hyunjin | - |
dc.contributor.author | Kim, Kiwon | - |
dc.contributor.author | Kim, Hyo Sang | - |
dc.contributor.author | Oh, Kook-Hwan | - |
dc.contributor.author | Yu, Su Jong | - |
dc.contributor.author | Chung, Jin Wook | - |
dc.contributor.author | Cho, Jeong Yeon | - |
dc.contributor.author | Kim, Seung Hyup | - |
dc.contributor.author | Cheong, Hae Il | - |
dc.contributor.author | Lee, Kyubeck | - |
dc.contributor.author | Park, Jong Hoon | - |
dc.contributor.author | Pei, York | - |
dc.contributor.author | Hwang, Young-Hwan | - |
dc.contributor.author | Ahn, Curie | - |
dc.date.available | 2021-02-22T11:32:16Z | - |
dc.date.issued | 2015-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10171 | - |
dc.description.abstract | Mass effect from polycystic kidney and liver enlargement can result in significant clinical complications and symptoms in autosomal dominant polycystic kidney disease (ADPKD). In this single-center study, we examined the correlation of height-adjusted total liver volume (htTLV) and total kidney volume (htTKV) by CT imaging with hepatic complications (n = 461) and abdominal symptoms (n = 253) in patients with ADPKD. "Mass-effect" complications were assessed by review of medical records and abdominal symptoms, by a standardized research questionnaire. Overall, 91.8% of patients had 4 or more liver cysts on CT scans. Polycystic liver disease (PLD) was classified as none or mild (htTLV < 1,600 mL/m); moderate (1,600 <= htTLV < 3,200 mL/m); and severe (htTLV >= 3,200 mL/m). The prevalence of moderate and severe PLD in our patient cohort was 11.7% (n = 54/461) and 4.8%(n = 22/461), respectively, with a female predominance in both the moderate (61.1%) and severe (95.5%) PLD groups. Pressure-related complications such as leg edema (20.4%), ascites (16.6%), and hernia (3.6%) were common, and patients with moderate to severe PLD exhibited a 6-fold increased risk (compared to no or mild PLD) for these complications in multivariate analysis. Similarly, abdominal symptoms including back pain (58.8%), flank pain (53.1%), abdominal fullness (46.5%), and dyspnea/chest-discomfort (44.3%) were very common, and patients with moderate to severe PLD exhibited a 5-fold increased risk for these symptoms. Moderate to severe PLD is a common and clinically important problem in similar to 16% of patients with ADPKD who may benefit from referral to specialized centers for further management. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Clinical Correlates of Mass Effect in Autosomal Dominant Polycystic Kidney Disease | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1371/journal.pone.0144526 | - |
dc.identifier.scopusid | 2-s2.0-84955595978 | - |
dc.identifier.wosid | 000366902700141 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.10, no.12 | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 10 | - |
dc.citation.number | 12 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | LIVER INVOLVEMENT | - |
dc.subject.keywordPlus | HEPATIC CYSTS | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | VOLUME | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | THERAPY | - |
dc.identifier.url | https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0144526 | - |
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