In vitro neuroprotective activity of sesquiterpenoids from the flower buds of Tussilago farfara
DC Field | Value | Language |
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dc.contributor.author | Lim, Hyo Jin | - |
dc.contributor.author | Dong, Guang-zhi | - |
dc.contributor.author | Lee, Hwa Jin | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.date.available | 2021-02-22T11:32:46Z | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 1475-6366 | - |
dc.identifier.issn | 1475-6374 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10214 | - |
dc.description.abstract | We have isolated four sesquiterpenoids from Tussilago farfara, a traditional herbal medicine in Korea and China, and investigated the protective effects on LPS-induced neuronal cell death. Four sesquiterpenoids inhibited the production of nitric oxide, prostaglandin E2 and tumor necrosis factor-a in LPS-treated BV-2 cells through the inhibition of NF-kappa B pathway. These sesquiterpenoids also inhibited reactive oxygen species (ROS) generation in LPS-treated BV-2 cells. Furthermore, they inhibited LPS-induced neuronal cell death in co-culture system through the inhibition of NF-kappa B pathway and scavenging of ROS. These results indicated that sesquiterpenoids from Tussilago farfara may have beneficial therapeutic potential for the treatment of neurodegenerative diseases through inhibition of microglial activation. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | In vitro neuroprotective activity of sesquiterpenoids from the flower buds of Tussilago farfara | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.3109/14756366.2014.965701 | - |
dc.identifier.scopusid | 2-s2.0-84940737617 | - |
dc.identifier.wosid | 000361328700017 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, v.30, no.5, pp 852 - 856 | - |
dc.citation.title | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | - |
dc.citation.volume | 30 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 852 | - |
dc.citation.endPage | 856 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.subject.keywordPlus | MICROGLIA | - |
dc.subject.keywordPlus | ALZHEIMER | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | sesquiterpenoids | - |
dc.subject.keywordAuthor | Tussilago farfara | - |
dc.identifier.url | https://www.tandfonline.com/doi/full/10.3109/14756366.2014.965701 | - |
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