Diarylheptanoids from lesser galangal suppress human colon cancer cell growth through modulating Wnt/beta-catenin pathway
DC Field | Value | Language |
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dc.contributor.author | Dong, Guang-zhi | - |
dc.contributor.author | Lee, So Yoon | - |
dc.contributor.author | Zhao, Hui-Yuan | - |
dc.contributor.author | Lee, Yu-ih | - |
dc.contributor.author | Jeong, Ji Hye | - |
dc.contributor.author | Jeon, Raok | - |
dc.contributor.author | Lee, Hwa Jin | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.date.available | 2021-02-22T11:32:49Z | - |
dc.date.issued | 2015-10 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.issn | 2214-9414 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10217 | - |
dc.description.abstract | The Wnt/beta-catenin pathway plays a central role in cell growth and differentiation but abnormal activation causes colorectal carcinogenesis. Inhibiting the Wnt/beta-catenin pathway can be a good strategy for chemoprevention and treatment of colorectal cancer. While screening for Wnt/beta-catenin pathway inhibitors from food materials, we found that (E)-7-(4-hydroxy3-methoxyphenyl)-1-phenylhept-4-en-3-one (compound 1), among six diarylheptanoids from lesser galangal (Alpinia officinarum), most potently suppressed Wnt3a-induced beta-catenin/T-cell factor activity. Moreover, compound 1 suppressed proliferation of colon cancer cells by inhibiting beta-catenin translocation to the nucleus by disrupting the beta-catenin/galectin-3 complex. Furthermore, a structure-activity realtionship study implicated that the enone group in the linker is critical and the hydroxy substituent on the aromatic ring is generally preferred for activity. Our findings suggest that diarylheptanoid from lesser galangal exerts anti-colon cancer activity by down regulating the Wnt/beta-catenin pathway. Bioactive diarylheptanoids and the basic understanding of their structure-activity relationship could be utilized to develop potential candidates for beta-catenin-targeted cancer treatment. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER | - |
dc.title | Diarylheptanoids from lesser galangal suppress human colon cancer cell growth through modulating Wnt/beta-catenin pathway | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jff.2015.06.059 | - |
dc.identifier.scopusid | 2-s2.0-84942520943 | - |
dc.identifier.wosid | 000367757400006 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.18, pp 47 - 57 | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 18 | - |
dc.citation.startPage | 47 | - |
dc.citation.endPage | 57 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | ALPINIA-OFFICINARUM | - |
dc.subject.keywordPlus | BETA-CATENIN | - |
dc.subject.keywordPlus | RHIZOMES | - |
dc.subject.keywordPlus | GALECTIN-3 | - |
dc.subject.keywordPlus | CURCUMA | - |
dc.subject.keywordAuthor | Alpinia officinarum | - |
dc.subject.keywordAuthor | Colon cancer | - |
dc.subject.keywordAuthor | Diarylheptanoid | - |
dc.subject.keywordAuthor | Lesser galangal | - |
dc.subject.keywordAuthor | Wnt/beta-catenin pathway | - |
dc.subject.keywordAuthor | Galectin-3 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S1756464615003539?via%3Dihub | - |
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