Inhibitors of inducible nitric oxide synthase expression from Artemisia iwayomogi
DC Field | Value | Language |
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dc.contributor.author | Ahn, H | - |
dc.contributor.author | Kim, JY | - |
dc.contributor.author | Lee, HJ | - |
dc.contributor.author | Kim, YK | - |
dc.contributor.author | Ryu, JH | - |
dc.date.available | 2021-02-22T11:33:40Z | - |
dc.date.issued | 2003-04 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10316 | - |
dc.description.abstract | Nitric oxide (NO) is an important bioactive agent that mediates a wide variety of physiological and pathophysiological events. NO overproduction by inducible nitric oxide synthase (iNOS) results in severe hypotension and inflammation. This investigation is part of a study to discover new iNOS inhibitors from medicinal plants using a macrophage cell culture system. Two sesquiterpenes (1 and 2) were isolated from Artemisia iwayomogi (Compositae) and were found to inhibit NO synthesis (IC50 3.64 mug/mL and 2.81 mug/mL, respectively) in lipopolysaccharide (LPS)-activated RAW 264.7 cells. Their structures were identified as 3-O-methyl-isosecotanapartholide (1) and iso-secotanapartholide (2). Compounds 1 and 2 inhibited the LPS-induced expression of the iNOS enzyme in the RAW 264.7 cells. The inhibition of NO production via the down regulation of iNOS expression may substantially modulate the inflammatory responses. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOCIETY KOREA | - |
dc.title | Inhibitors of inducible nitric oxide synthase expression from Artemisia iwayomogi | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/BF02976959 | - |
dc.identifier.scopusid | 2-s2.0-0642343128 | - |
dc.identifier.wosid | 000182563700009 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.26, no.4, pp 301 - 305 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 26 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 301 | - |
dc.citation.endPage | 305 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART000917648 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | LPS-ACTIVATED MACROPHAGES | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | CONSTITUENTS | - |
dc.subject.keywordPlus | COMBINATION | - |
dc.subject.keywordPlus | ENZYME | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | Artemisia iwayomogi | - |
dc.subject.keywordAuthor | nitric oxide synthase | - |
dc.subject.keywordAuthor | sesquiterpene | - |
dc.subject.keywordAuthor | inhibitor | - |
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