Emodin isolated from Rheum palmatum prevents cytokine-induced beta-cell damage and the development of type 1 diabetes
DC Field | Value | Language |
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dc.contributor.author | Bae, Ui-Jin | - |
dc.contributor.author | Song, Mi-Young | - |
dc.contributor.author | Jang, Hyun-Young | - |
dc.contributor.author | Lim, Jung Min | - |
dc.contributor.author | Lee, So Yoon | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.contributor.author | Park, Byung-Hyun | - |
dc.date.available | 2021-02-22T11:35:25Z | - |
dc.date.issued | 2015-06 | - |
dc.identifier.issn | 1756-4646 | - |
dc.identifier.issn | 2214-9414 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10518 | - |
dc.description.abstract | Emodin is an anthraquinone derivative from rhubarb and buckthorn, and is also produced by many species of fungi. Although its anti-diabetic effect in type 2 diabetes has been reported, the potential effects of emodin on type 1 diabetes remain unclear. Therefore, in this study, we isolated emodin from rhubarb (Rheum palmatum) and investigated its effects on cytokine- or streptozotocin-induced beta-cell damage and dysfunction. Emodin protected RINm5F cells or mouse islets against cytokine-induced damage by suppressing inducible nitric oxide synthase expression and nitric oxide production. The cytoprotective potential of emodin was associated with the inhibition of NF-kappa B signaling by reducing I kappa B kinase activity. The protective effects of emodin were further demonstrated by normalizing insulin secretion of cytokine-treated islets in response to glucose. In multiple low-dose streptozotocin-induced diabetes model, emodin-pretreated mice were fully resistant to the development of diabetes with normal islet morphology and insulin secretion. Immunohistochemical analysis revealed that emodin significantly decreased the number of TUNEL-positive and nuclear p65-positive pancreatic islets. These results suggest that emodin blocks the NF-kappa 3 pathway, thus protecting beta-cells against diabetogenic insults. Emodin may have therapeutic value in preventing the development of type 1 diabetes by delaying the process of insulitis and by protecting against beta-cell damage. (C) 2015 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.title | Emodin isolated from Rheum palmatum prevents cytokine-induced beta-cell damage and the development of type 1 diabetes | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.jff.2015.04.016 | - |
dc.identifier.scopusid | 2-s2.0-84937545556 | - |
dc.identifier.wosid | 000357905100002 | - |
dc.identifier.bibliographicCitation | JOURNAL OF FUNCTIONAL FOODS, v.16, pp 9 - 19 | - |
dc.citation.title | JOURNAL OF FUNCTIONAL FOODS | - |
dc.citation.volume | 16 | - |
dc.citation.startPage | 9 | - |
dc.citation.endPage | 19 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalResearchArea | Nutrition & Dietetics | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Nutrition & Dietetics | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | ISLET GRAFT | - |
dc.subject.keywordPlus | PANCREATIC-ISLETS | - |
dc.subject.keywordPlus | PROINFLAMMATORY CYTOKINES | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DEATH | - |
dc.subject.keywordAuthor | Emodin | - |
dc.subject.keywordAuthor | NF-kappa B | - |
dc.subject.keywordAuthor | Cytokine | - |
dc.subject.keywordAuthor | Streptozotocin | - |
dc.subject.keywordAuthor | Diabetes | - |
dc.subject.keywordAuthor | Apoptosis | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S1756464615001899?via%3Dihub | - |
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