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Emodin isolated from Rheum palmatum prevents cytokine-induced beta-cell damage and the development of type 1 diabetes

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dc.contributor.authorBae, Ui-Jin-
dc.contributor.authorSong, Mi-Young-
dc.contributor.authorJang, Hyun-Young-
dc.contributor.authorLim, Jung Min-
dc.contributor.authorLee, So Yoon-
dc.contributor.authorRyu, Jae-Ha-
dc.contributor.authorPark, Byung-Hyun-
dc.date.available2021-02-22T11:35:25Z-
dc.date.issued2015-06-
dc.identifier.issn1756-4646-
dc.identifier.issn2214-9414-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10518-
dc.description.abstractEmodin is an anthraquinone derivative from rhubarb and buckthorn, and is also produced by many species of fungi. Although its anti-diabetic effect in type 2 diabetes has been reported, the potential effects of emodin on type 1 diabetes remain unclear. Therefore, in this study, we isolated emodin from rhubarb (Rheum palmatum) and investigated its effects on cytokine- or streptozotocin-induced beta-cell damage and dysfunction. Emodin protected RINm5F cells or mouse islets against cytokine-induced damage by suppressing inducible nitric oxide synthase expression and nitric oxide production. The cytoprotective potential of emodin was associated with the inhibition of NF-kappa B signaling by reducing I kappa B kinase activity. The protective effects of emodin were further demonstrated by normalizing insulin secretion of cytokine-treated islets in response to glucose. In multiple low-dose streptozotocin-induced diabetes model, emodin-pretreated mice were fully resistant to the development of diabetes with normal islet morphology and insulin secretion. Immunohistochemical analysis revealed that emodin significantly decreased the number of TUNEL-positive and nuclear p65-positive pancreatic islets. These results suggest that emodin blocks the NF-kappa 3 pathway, thus protecting beta-cells against diabetogenic insults. Emodin may have therapeutic value in preventing the development of type 1 diabetes by delaying the process of insulitis and by protecting against beta-cell damage. (C) 2015 Elsevier Ltd. All rights reserved.-
dc.format.extent11-
dc.language영어-
dc.language.isoENG-
dc.publisherELSEVIER SCIENCE BV-
dc.titleEmodin isolated from Rheum palmatum prevents cytokine-induced beta-cell damage and the development of type 1 diabetes-
dc.typeArticle-
dc.publisher.location네델란드-
dc.identifier.doi10.1016/j.jff.2015.04.016-
dc.identifier.scopusid2-s2.0-84937545556-
dc.identifier.wosid000357905100002-
dc.identifier.bibliographicCitationJOURNAL OF FUNCTIONAL FOODS, v.16, pp 9 - 19-
dc.citation.titleJOURNAL OF FUNCTIONAL FOODS-
dc.citation.volume16-
dc.citation.startPage9-
dc.citation.endPage19-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaFood Science & Technology-
dc.relation.journalResearchAreaNutrition & Dietetics-
dc.relation.journalWebOfScienceCategoryFood Science & Technology-
dc.relation.journalWebOfScienceCategoryNutrition & Dietetics-
dc.subject.keywordPlusNF-KAPPA-B-
dc.subject.keywordPlusISLET GRAFT-
dc.subject.keywordPlusPANCREATIC-ISLETS-
dc.subject.keywordPlusPROINFLAMMATORY CYTOKINES-
dc.subject.keywordPlusSIGNAL-TRANSDUCTION-
dc.subject.keywordPlusPROTECTS-
dc.subject.keywordPlusTRANSPLANTATION-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusDEATH-
dc.subject.keywordAuthorEmodin-
dc.subject.keywordAuthorNF-kappa B-
dc.subject.keywordAuthorCytokine-
dc.subject.keywordAuthorStreptozotocin-
dc.subject.keywordAuthorDiabetes-
dc.subject.keywordAuthorApoptosis-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S1756464615001899?via%3Dihub-
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