No increase in blood-brain barrier permeability after intraperitoneal injection of endotoxin in the rat
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 강영숙 | - |
dc.contributor.author | Bickel, U. | - |
dc.contributor.author | Grave, B. | - |
dc.contributor.author | Del Rey, A. | - |
dc.contributor.author | Voigt, K. | - |
dc.date.available | 2021-02-22T11:35:57Z | - |
dc.date.issued | 1998-05 | - |
dc.identifier.issn | 0165-5728 | - |
dc.identifier.issn | 1872-8421 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10576 | - |
dc.description.abstract | Reactions mediated by the brain are part of the response to intraperitoneal administration of endotoxin, a model of gram-negative bacterial infection. To test the hypothesis that a compromised blood-brain barrier (BBB) may contribute to these reactions, the integrity of the BBB was measured following lipopolysaccharide administration. Rats received intraperitoneal injections of 50 μg/kg or 2 mg/kg of endotoxin. Brain uptake of a macromolecular vascular marker, 3H-labelled rat serum albumin, and of a poorly permeable low molecular weight substance, [14C]sucrose, was then measured with the intravenous bolus injection method. Compared to controls, neither dose of endotoxin affected the BBB permeability for these tracers. This was true when brain uptake was measured 5 min or 2 h after lipopolysaccharide injection. It is concluded that intraperitoneal endotoxin even at a high dose does not acutely disrupt the BBB. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | No increase in blood-brain barrier permeability after intraperitoneal injection of endotoxin in the rat | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/S0165-5728(98)00004-6 | - |
dc.identifier.scopusid | 2-s2.0-0032524174 | - |
dc.identifier.wosid | 000074038100004 | - |
dc.identifier.bibliographicCitation | Journal of Neuroimmunology, v.85, no. 2, pp 131 - 136 | - |
dc.citation.title | Journal of Neuroimmunology | - |
dc.citation.volume | 85 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 131 | - |
dc.citation.endPage | 136 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordAuthor | Blood–brain barrier | - |
dc.subject.keywordAuthor | Rat | - |
dc.subject.keywordAuthor | Lipopolysaccharide | - |
dc.subject.keywordAuthor | Sucrose | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0165572898000046 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.