Kazinol C from Broussonetia kazinoki activates AMP-activated protein kinase to induce antitumorigenic effects in HT-29 colon cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Hak-Su | - |
dc.contributor.author | Lim, Jihyun | - |
dc.contributor.author | Lee, Da Yeon | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.contributor.author | Lim, Jong-Seok | - |
dc.date.available | 2021-02-22T11:46:24Z | - |
dc.date.issued | 2015-01 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.issn | 1791-2431 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10704 | - |
dc.description.abstract | Kazinol C is a 1,3-diphenylpropane, obtained from Broussonetia kazinoki, that has been employed in folk medicine as an edema suppressant. It exerts beneficial effects in oxidative stress-related diseases, such as cancer. However, the molecular mechanism involved in the anticancer effects remains to be determined. AMP-activated protein kinase (AMPK) has emerged as a possible anticancer target molecule. The present study investigated the effect of kazinol C on AMPK activation as well as subsequent HT-29 colon cancer cell viability, apoptosis and migration. Kazinol C markedly induced AMPK phosphorylation and significantly attenuated HT-29 colon cancer cell growth and viability. Compound C, as a well-known AMPK inhibitor, blocked the kazinol C-induced cell death, and stable transduction of dominant-negative (DN) AMPK in colon cancer cells also inhibited kazinol C-induced cell apoptosis. In addition, kazinol C inhibited HT-29 cell migration and anchorage-independent growth. AMPK inhibition using stable transduction with DN AMPK significantly abrogated the kazinol C-induced inhibition of cancer cell migration. Thus, AMPK is a critical and novel regulator of kazinol C-mediated cancer cell apoptosis and inhibition of migration, suggesting that AMPK is a prime cancer target. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPANDIDOS PUBL LTD | - |
dc.title | Kazinol C from Broussonetia kazinoki activates AMP-activated protein kinase to induce antitumorigenic effects in HT-29 colon cancer cells | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.3892/or.2014.3601 | - |
dc.identifier.scopusid | 2-s2.0-84916212079 | - |
dc.identifier.wosid | 000346636200029 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, v.33, no.1, pp 223 - 229 | - |
dc.citation.title | ONCOLOGY REPORTS | - |
dc.citation.volume | 33 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 223 | - |
dc.citation.endPage | 229 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | ISOPRENYLATED FLAVANS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | METABOLISM | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | QUERCETIN | - |
dc.subject.keywordAuthor | kazinol C | - |
dc.subject.keywordAuthor | AMP-activated protein kinase | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | migration | - |
dc.subject.keywordAuthor | colon cancer | - |
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