Nuclease Delivery: Versatile Functions of SLX4/FANCP in Genome Maintenance
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yonghwan | - |
dc.date.available | 2021-02-22T11:47:42Z | - |
dc.date.issued | 2014-08 | - |
dc.identifier.issn | 1016-8478 | - |
dc.identifier.issn | 0219-1032 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10816 | - |
dc.description.abstract | As a scaffold, SLX4/FANCP interacts with multiple proteins involved in genome integrity. Although not having recognizable catalytic domains, SLX4 participates in diverse genome maintenance pathways by delivering nucleases where they are needed, and promoting their cooperative execution to prevent genomic instabilities. Physiological importance of SLX4 is emphasized by the identification of causative mutations of SLX4 genes in patients diagnosed with Fanconi anemia (FA), a rare recessive genetic disorder characterized by genomic instability and predisposition to cancers. Recent progress in understanding functional roles of SLX4 has greatly expanded our knowledge in the repair of DNA interstrand crosslinks (ICLs), Holliday junction (HJ) resolution, telomere homeostasis and regulation of DNA damage response induced by replication stress. Here, these diverse functions of SLX4 are reviewed in detail. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOC MOLECULAR & CELLULAR BIOLOGY | - |
dc.title | Nuclease Delivery: Versatile Functions of SLX4/FANCP in Genome Maintenance | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.14348/molcells.2014.0118 | - |
dc.identifier.scopusid | 2-s2.0-84930252372 | - |
dc.identifier.wosid | 000342561500001 | - |
dc.identifier.bibliographicCitation | MOLECULES AND CELLS, v.37, no.8, pp 569 - 574 | - |
dc.citation.title | MOLECULES AND CELLS | - |
dc.citation.volume | 37 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 569 | - |
dc.citation.endPage | 574 | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART001907059 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | CROSS-LINK REPAIR | - |
dc.subject.keywordPlus | HOLLIDAY JUNCTION RESOLUTION | - |
dc.subject.keywordPlus | STRUCTURE-SPECIFIC ENDONUCLEASES | - |
dc.subject.keywordPlus | FANCONI ANEMIA/BRCA PATHWAY | - |
dc.subject.keywordPlus | DNA-REPAIR | - |
dc.subject.keywordPlus | HOMOLOGOUS RECOMBINATION | - |
dc.subject.keywordPlus | SLX4 | - |
dc.subject.keywordPlus | MUS81-EME1 | - |
dc.subject.keywordPlus | RESOLVASE | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordAuthor | fanconi anemia | - |
dc.subject.keywordAuthor | Holliday junction | - |
dc.subject.keywordAuthor | ICL repair | - |
dc.subject.keywordAuthor | SLX4/FANCP | - |
dc.subject.keywordAuthor | telomere maintenance | - |
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