Therapeutic implications of microRNAs in pulmonary arterial hypertension
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Aram | - |
dc.contributor.author | McLean, Danielle | - |
dc.contributor.author | Choi, Jihea | - |
dc.contributor.author | Kang, Hyesoo | - |
dc.contributor.author | Chang, Woochul | - |
dc.contributor.author | Kim, Jongmin | - |
dc.date.available | 2021-02-22T11:48:24Z | - |
dc.date.issued | 2014-06-30 | - |
dc.identifier.issn | 1976-6696 | - |
dc.identifier.issn | 1976-670X | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10869 | - |
dc.description.abstract | microRNAs (miRNAs) are a class of small, non-coding RNAs that play critical posttranscriptional regulatory roles typically through targeting of the 3'-untranslated region of messenger RNA (mRNA). Mature miRNAs are known to be involved in global cellular processes, such as differentiation, proliferation, apoptosis, and organogenesis, due to their capacity to target multiple mRNAs. Thus, imbalances in the expression and/or activity of miRNAs are involved in the pathogenesis of numerous diseases, including pulmonary arterial hypertension (PAH). PAH is a progressive disease characterized by vascular remodeling due to excessive proliferation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs). Recently, studies have evaluated the roles of miRNAs involved in the pathogenesis of PAH in these pulmonary vascular cells. This review provides an overview of recent discoveries on the role of miRNAs in the pathogenesis of PAH and discusses the potential for miRNAs as therapeutic targets and biomarkers of PAH. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY | - |
dc.title | Therapeutic implications of microRNAs in pulmonary arterial hypertension | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5483/BMBRep.2014.47.6.085 | - |
dc.identifier.scopusid | 2-s2.0-84903603318 | - |
dc.identifier.wosid | 000338696400002 | - |
dc.identifier.bibliographicCitation | BMB REPORTS, v.47, no.6, pp 311 - 317 | - |
dc.citation.title | BMB REPORTS | - |
dc.citation.volume | 47 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 311 | - |
dc.citation.endPage | 317 | - |
dc.type.docType | Review | - |
dc.identifier.kciid | ART001883449 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | BONE MORPHOGENETIC PROTEIN | - |
dc.subject.keywordPlus | SMOOTH-MUSCLE-CELLS | - |
dc.subject.keywordPlus | CHRONIC HYPOXIA | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordPlus | RNAS | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | BIOGENESIS | - |
dc.subject.keywordAuthor | Biomarker | - |
dc.subject.keywordAuthor | microRNA | - |
dc.subject.keywordAuthor | Pulmonary arterial hypertension | - |
dc.subject.keywordAuthor | Pulmonary vascular cell | - |
dc.subject.keywordAuthor | Signaling pathway | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.