Interaction with the Surrounding Water Plays a Key Role in Determining the Aggregation Propensity of Proteins
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chong, Song-Ho | - |
dc.contributor.author | Ham, Sihyun | - |
dc.date.available | 2021-02-22T11:48:46Z | - |
dc.date.issued | 2014-04 | - |
dc.identifier.issn | 1433-7851 | - |
dc.identifier.issn | 1521-3773 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/10907 | - |
dc.description.abstract | Understanding the molecular determinants of the relative propensities of proteins to aggregate in a cellular environment is a central issue for treating protein-aggregation diseases and developing peptide-based therapeutics. Despite the expectation that protein aggregation can largely be attributed to direct protein-protein interactions, a crucial role the surrounding water in determining the aggregation propensity of proteins both invitro and invivo was identified. The overall protein hydrophobicity, defined solely by the hydration free energy of a protein in its monomeric state sampling its equilibrium structures, was shown to be the predominant determinant of protein aggregation propensity in aqueous solution. Striking discrimination of positively and negatively charged residues by the surrounding water was also found. This effect depends on the protein net charge and plays a crucial role in regulating the solubility of the protein. These results pave the way for the design of aggregation-resistant proteins as biotherapeutics. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.title | Interaction with the Surrounding Water Plays a Key Role in Determining the Aggregation Propensity of Proteins | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/anie.201309317 | - |
dc.identifier.scopusid | 2-s2.0-84898078783 | - |
dc.identifier.wosid | 000333634800034 | - |
dc.identifier.bibliographicCitation | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.53, no.15, pp 3961 - 3964 | - |
dc.citation.title | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | - |
dc.citation.volume | 53 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 3961 | - |
dc.citation.endPage | 3964 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | SEQUENCE DETERMINANTS | - |
dc.subject.keywordPlus | PREDICTION | - |
dc.subject.keywordPlus | AMYLOIDOGENICITY | - |
dc.subject.keywordPlus | THERMODYNAMICS | - |
dc.subject.keywordPlus | SOLUBILITY | - |
dc.subject.keywordPlus | HYDRATION | - |
dc.subject.keywordPlus | PEPTIDES | - |
dc.subject.keywordAuthor | amyloid beta-peptides | - |
dc.subject.keywordAuthor | hydrophobic effect | - |
dc.subject.keywordAuthor | proteins | - |
dc.subject.keywordAuthor | thermodynamics | - |
dc.subject.keywordAuthor | water | - |
dc.identifier.url | https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201309317 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.